Publications

  • Dahlgren, David; Cano-Cebrian, Maria-Jose; Olander, Tobias; Hedeland, Mikael et al.

    Regional Intestinal Drug Permeability and Effects of Permeation Enhancers in Rat

    Part of Pharmaceutics, 2020.

    Open access
  • Dahlgren, David; Sjöblom, Markus; Hedeland, Mikael; Lennernäs, Hans

    The In Vivo Effect of Transcellular Permeation Enhancers on the Intestinal Permeability of Two Peptide Drugs Enalaprilat and Hexarelin

    Part of Pharmaceutics, 2020.

    Open access
  • Dahlgren, David; Sjöblom, Markus; Lennernäs, Hans

    Intestinal absorption-modifying excipients: A current update on preclinical in vivo evaluations

    Part of European journal of pharmaceutics and biopharmaceutics, p. 411-420, 2019.

  • Roos, Carl; Dahlgren, David; Sjögren, Erik; Sjöblom, Markus et al.

    Effects of absorption-modifying excipients on jejunal drug absorption in simulated fasted and fed luminal conditions

    Part of European journal of pharmaceutics and biopharmaceutics, p. 387-395, 2019.

  • Dahlgren, David; Roos, Carl; Peters, Karsten; Lundqvist, A. et al.

    Evaluation of drug permeability calculation based on luminal disappearance and plasma appearance in the rat single-pass intestinal perfusion model

    Part of European journal of pharmaceutics and biopharmaceutics, p. 31-37, 2019.

  • Roos, Carl; Dahlgren, David; Sjögren, Erik; Sjöblom, Markus et al.

    Jejunal absorption of aprepitant from nanosuspensions: Role of particle size, prandial state and mucus layer.

    Part of European journal of pharmaceutics and biopharmaceutics, p. 222-230, 2018.

  • Dahlgren, David; Roos, Carl; Lundqvist, A.; Tannergren, C. et al.

    Time-dependent effects on small intestinal transport by absorption-modifying excipients

    Part of European journal of pharmaceutics and biopharmaceutics, p. 19-28, 2018.

  • Dahlgren, David; Roos, Carl; Johansson, P; Tannergren, C et al.

    The effects of three absorption-modifying critical excipients on the in vivo intestinal absorption of six model compounds in rats and dogs.

    Part of International Journal of Pharmaceutics, p. 158-168, 2018.

  • Dahlgren, David; Roos, Carl; Lundqvist, A; Tannergren, C et al.

    Effect of absorption-modifying excipients, hypotonicity, and enteric neural activity in an in vivo model for small intestinal transport.

    Part of International Journal of Pharmaceutics, p. 239-248, 2018.

  • Dahlgren, David; Roos, Carl; Lundqvist, Anders; Tannergren, Christer et al.

    Preclinical Effect of Absorption Modifying Excipients on Rat Intestinal Transport of Model Compounds and the Mucosal Barrier Marker 51Cr-EDTA

    Part of Molecular Pharmaceutics, p. 4243-4251, 2017.

  • Wan Saudi, Wan Salman; Sjöblom, Markus

    Neuropeptide S reduces duodenal bicarbonate secretion and ethanol-induced increases in duodenal motility in rats

    Part of PLoS ONE, 2017.

    Open access
  • Wan Saudi, Wan Salman; Sjöblom, Markus

    Short-chain fatty acids augment rat duodenal mucosal barrier function

    Part of Experimental Physiology, p. 791-803, 2017.

  • Wan Saudi, Wan Salman; Halim, Mohammed Abdul; Gillberg, Linda; Rudholm-Feldreich, Tobias et al.

    Neuropeptide S inhibits gastrointestinal motility and increases mucosal permeability through nitric oxide

    Part of American Journal of Physiology - Gastrointestinal and Liver Physiology, p. G625-G634, 2015.

  • Sommansson, Anna; Yamskova, Olga; Schiöth, Helgi B.; Nylander, Olof et al.

    Long-term oral melatonin administration reduces ethanol-induced increases in duodenal mucosal permeability and motility in rats

    Part of Acta Physiologica, p. 152-165, 2014.

  • Sommansson, Anna; Saudi, Wan Salman Wan; Nylander, Olof; Sjöblom, Markus

    The Ethanol-Induced Stimulation of Rat Duodenal Mucosal Bicarbonate Secretion In Vivo Is Critically Dependent on Luminal Cl-

    Part of PLoS ONE, p. e102654-, 2014.

    Open access
  • Sedin, John; Sjöblom, Markus; Nylander, Olof

    Prevention of duodenal ileus reveals functional differences in the duodenal response to luminal hypertonicity in Sprague-Dawley and Dark Agouti rats

    Part of Acta Physiologica, p. 573-589, 2014.

  • Sommansson, Anna; Saudi, Wan Salman Wan; Nylander, Olof; Sjöblom, Markus

    Melatonin inhibits alcohol-induced increases in duodenal mucosal permeability in rats in vivo

    Part of American Journal of Physiology - Gastrointestinal and Liver Physiology, p. G95-G105, 2013.

  • Sjöblom, Markus; Lindqvist, Ramin; Bengtsson, Magnus W.; Jedstedt, Gunilla et al.

    Cholecystokinin but not ghrelin stimulates mucosal bicarbonate secretion in rat duodenum: Independence of feeding status and cholinergic stimuli

    Part of Regulatory Peptides, p. 46-53, 2013.

  • Sommansson, Anna; Nylander, Olof; Sjöblom, Markus

    Melatonin decreases duodenal epithelial paracellular permeability via a nicotinic receptor-dependent pathway in rats in vivo

    Part of Journal of Pineal Research, p. 282-291, 2013.

  • Sedin, John; Sjöblom, Markus; Nylander, Olof

    The selective cyclooxygenase-2 inhibitor parecoxib markedly improves the ability of the duodenum to regulate luminal hypertonicity in anaesthetized rats

    Part of Acta Physiologica, p. 433-451, 2012.

  • Flemström, Gunnar; Mäkelä, Kari; Purhonen, Anna-Kaisa; Sjöblom, Markus et al.

    Apelin stimulation of duodenal bicarbonate secretion: feeding-dependent and mediated via apelin-induced release of enteric cholecystokinin

    Part of Acta Physiologica, p. 141-150, 2011.

  • Sjöblom, Markus

    Duodenal epithelial sensing of luminal acid: role of carbonic anhydrases

    Part of Acta Physiologica, p. 85-95, 2011.

  • Pihl, Liselotte; Sjöblom, Markus; Seidler, U.; Sedin, John et al.

    Motility-induced but not vasoactive intestinal peptide-induced increase in luminal alkalinization in rat duodenum is dependent on luminal Cl-

    Part of Acta Physiologica, p. 181-191, 2010.

  • Sjöblom, Markus; Singh, Anurag Kumar; Zheng, Wen; Wang, Jian et al.

    Duodenal acidity "sensing" but not epithelial HCO3- supply is critically dependent on carbonic anhydrase II expression

    Part of Proceedings of the National Academy of Sciences of the United States of America, p. 13094-13099, 2009.

  • Zheng, Wen; Kuhlicke, Johannes; Jäckel, Kristian; Eltzschig, Holger K et al.

    Hypoxia inducible factor-1 (HIF-1)-mediated repression of cystic fibrosis transmembrane conductance regulator (CFTR) in the intestinal epithelium.

    Part of The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, p. 204-213, 2009.

  • Singh, A K; Sjöblom, Markus; Zheng, W; Krabbenhöft, A et al.

    CFTR and its key role in in vivo resting and luminal acid-induced duodenal HCO3-secretion

    Part of Acta Physiologica, p. 357-365, 2008.

  • Bengtsson, Magnus W.; Mäkelä, Kari; Sjöblom, Markus; Uotila, Sanna et al.

    Food-induced expression of orexin receptors in rat duodenal mucosa regulates the bicarbonate secretory response to orexin-A

    Part of American Journal of Physiology - Gastrointestinal and Liver Physiology, p. G501-G509, 2007.

  • Nylander, Olof; Sjöblom, Markus

    Modulation of mucosal permeability by vasoactive intestinal peptide or lidocaine affects the adjustment of luminal hypotonicity in rat duodenum

    Part of Acta Physiologica, p. 325-335, 2007.

  • Sjöblom, Markus; Nylander, Olof

    Isoflurane-induced acidosis depresses basal and PGE(2)-stimulated duodenal bicarbonate secretion in mice

    Part of American Journal of Physiology - Gastrointestinal and Liver Physiology, p. G899-G904, 2007.

  • Säfsten, Bengt; Sjöblom, Markus; Flemström, Gunnar

    Serotonin increases protective duodenal bicarbonate secretion via enteric ganglia and a 5-HT4-dependent pathway

    Part of Scandinavian Journal of Gastroenterology, p. 1279-1289, 2006.

  • Leppilampi, Mari; Parkkila, Seppo; Karttunen, Tuomo; Gut, Marta Ortova et al.

    Carbonic anhydrase isozyme-II-deficient mice lack the duodenal bicarbonate secretory response to prostaglandin E2.

    Part of Proc Natl Acad Sci U S A, p. 15247-52, 2005.

  • Sjöblom, Markus

    The duodenal mucosal bicarbonate secretion.

    Part of Ups J Med Sci, p. 115-49, 2005.

  • Flemström, Gunnar; Sjöblom, Markus

    Epithelial Cells and Their Neighbors: II. New perspectives on efferent signaling between brain, neuroendocrine cells, and gut epithelial cells

    Part of American Journal of Physiology - Gastrointestinal and Liver Physiology, p. G377-G380, 2005.

  • Sjöblom, Markus; Flemström, Gunnar

    Central nervous alpha1-adrenoceptor stimulation induces duodenal luminal release of melatonin.

    Part of J Pineal Res, p. 103-8, 2004.

  • Flemström, Gunnar; Sjöblom, Markus; Jedstedt, Gunilla; Åkerman, Karl EO

    Short fasting dramatically decreases rat duodenal secretory responsiveness to orexin A but not to VIP or melatonin

    Part of American Journal of Physiology - Gastrointestinal and Liver Physiology, p. G1091-G1096, 2003.

  • Sjöblom, Markus; Säfsten, Bengt; Flemström, Gunnar

    Melatonin-induced calcium signaling in clusters of human and rat duodenal enterocytes

    Part of American Journal of Physiology - Gastrointestinal and Liver Physiology, p. G1034-G1044, 2003.

  • Sjöblom, Markus; Flemström, Gunnar

    Melatonin in the duodenal lumen is a potent stimulant of mucosal bicarbonate secretion

    Part of Journal of Pineal Research, p. 288-293, 2003.

  • Flemström, Gunnar; Sjöblom, Markus

    Duodenal defence mechanisms:: Role of mucosal bicarbonate secretion

    Part of InflammoPharmacology, p. 327-332, 2002.

  • Sjöblom, Markus; Flemström, Gunnar

    Central nervous stimuli increase duodenal bicarbonate secretion by release of mucosal melatonin

    Part of J Physiology and Pharmacology, p. 671 671-, 2001.

  • Sjöblom, Markus; Jedstedt, Gunilla; Flemström, Gunnar

    Peripheral melatonin mediates stimulation of duodenal mucosal bicarbonate secretion

    Part of J Clin Investigation, p. 625 625-, 2001.

  • Sjöblom, Markus; Jedstedt, Gunilla; Flemström, Gunnar

    Peripheral melatonin mediates neural stimulation of duodenal mucosal bicarbonate secretion

    Part of Journal of Clinical Investigation, p. 625 625-633 633, 2001.

  • Roos, Carl; Dahlgren, David; Sjögren, Erik; Sjöblom, Markus et al.

    Effects of absorption-modifying excipients on jejunal drug absorption in simulated fasted and fed luminal conditions

    Part of European journal of pharmaceutics and biopharmaceutics